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KMID : 0364519960080010143
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Dong-A Journal Medicine
1996 Volume.8 No. 1 p.143 ~ p.148
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A Case of Chlorquine-Resistant, Sever Falciparum Malaria with Myoglobinuria
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Bae Sung-Jin
Ham Jin-Yeong
Lim Young-Jin
Lee Sang-Do
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Abstract
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mported malaria is increasing recently. Africa and south-east Asia are the main origin, Malaria can cause mild febrile illness to severe fatal multiorgan failure in human, judicious selection and use of drugs are essential to overcome drug
resistance. We experienced a 27 year old male patient developed fever, chills, coughing, and oliguria 7 days after he came back from travel to kenya, prevalent area of chlorquine-ressistant malaria, for 10days. Increased CK enzyme level accompanied by myoglobinuria was noted, which is known very rare in malaria, and with additional findings of hypoglycemia, obtunded mentality, sever azotemia, and pulmonary edema. He could be categorized to sever malaria. With combination of intraveous quinine dihydrochloride and pyrimethamine and subsequent administration of quinine hydrochloride and doxycyclin, merozoites were disappeared within 4 days, and the patient was completely recovered from multiple organ injury during following several days.
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